American Serenade, Mississippi River

Mississippi River and Arkansas River

Free Internet
Riverview Cabins
Jacuzzi / Hot Tub
En-Suite bathrooms
Family Cabins
Aircon Cabins
Warm Water Showers

from $ 607/ night Check dates

Highlights

Multiple dining venues
Fitness center on board

Step aboard American Serenade, a riverboat accommodating 180 guests in oversized staterooms ranging from 250 to 650 sq. ft. (23-60 m2). Each cabin features private balconies, full-size bathrooms, and generous storage—ideal for longer journeys. Choose from a range of accommodations, including the palatial Grand Suite and dedicated Single Balcony rooms. With its award-winning design, American Serenade blends contemporary aesthetics with natural textures, offering a calm, elegant retreat as you cruise America’s rivers.

Beyond the staterooms, American Serenade invites guests to relax in multiple spacious lounges, enjoy a workout in the fitness center, or stroll the outdoor walking track. A stunning four-story glass atrium offers panoramic views, while elevator access to all decks ensures effortless mobility. Dining is a highlight, with multiple venues serving refined regional cuisine—from Creole classics to Heartland favorites—all prepared fresh daily and enjoyed against a backdrop of flowing river scenery.

Sail from St. Paul to New Orleans on a 16-day epic through the heart of the Mississippi, with stops in culturally rich towns like Hannibal, Memphis, and Natchez. Or opt for a shorter 8-day round trip from New Orleans, exploring the bayou’s soulful rhythms and grand plantations. With expert-guided excursions, engaging onboard lectures, and ever-changing views, each itinerary brings the vibrant spirit and layered history of the Mississippi to life.

Book your next river cruise aboard the American Serenade today.

Choose your departure date

Date

Itinerary

Price

Select

24 Apr

9 Days / 8 Nights

$ 5,495

FULL

01 May

9 Days / 8 Nights

$ 5,495

FULL

08 May

9 Days / 8 Nights

$ 5,495

Select Cabin available

15 May

9 Days / 8 Nights

$ 5,495

FULL

22 May

9 Days / 8 Nights

$ 5,495

FULL

29 May

9 Days / 8 Nights

$ 5,495

FULL

05 Jun

9 Days / 8 Nights

$ 5,635

FULL

12 Jun

23 Days / 22 Nights

Up to $2000 OFF plus Free Airfare! Rates include discount. Valid for a limited time only.

$ 14,890 Deal %

Select Cabin available

03 Jul

9 Days / 8 Nights

Mark Twain Cruise!

$ 5,635

FULL

10 Jul

9 Days / 8 Nights

Mark Twain Cruise!

$ 5,635

Select Cabin available

17 Jul

9 Days / 8 Nights

$ 5,635

Select Cabin available

24 Jul

9 Days / 8 Nights

Up to $1200 OFF! Rates include discount. Valid for a limited time only.

$ 5,035 Deal %

Select Cabin available

Included: VAT, Port Fees, Alcoholic Beverages, Drinking Water, Soft drinks, Tea & Coffee, Welcome Cocktails, Wine with Dinner, Full-Board Meal Plan (All meals), Cabin Towels, Complimentary Toiletries, Deck Towels, Laundry / Pressing Services, WiFi internet.

Book now, pay later: You can easily place your booking online. We will then hold the spaces for you and you can confirm with a payment later.

* Extra fees are shown per person.

Pay by bank transfer or online with

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Boat features

Free Internet
Riverview Cabins
Jacuzzi / Hot Tub
En-Suite bathrooms
Family Cabins
Aircon Cabins
Warm Water Showers
Air Conditioned saloon
Sun Deck
Rooms with Balcony
Non-Smoking Rooms
Charging stations
Indoor Saloon
Laundry Service
Library
Outdoor Dining
Audio & video entertainment
TV in cabins
Observation Deck
BBQ Area
Leisure Deck
Daily housekeeping
Bar

Food & Drinks

Fine Cuisine
Al Fresco Dining
Vegan Options
Vegetarian Options
Free Soft Drinks
Beer available
Wine Available
Welcome Cocktails
Snacks All Day
Buffet style
Western Food
Local Food
Set Menu Dinner

If you have any specific dietary requirements whilst on-board your cruise, you can add this to your special requests on step 2 of the booking form. We advise limiting these requests to religious beliefs or food allergies.